Technology Process of N-(2-(4-(6-amino-9-ethyl-9H-purine-8-yl)-1H-1,2,3-triazol-1-yl)acetyl)-2-benzyloxycarbonylamino-3-methylbutanamide
There total 6 articles about N-(2-(4-(6-amino-9-ethyl-9H-purine-8-yl)-1H-1,2,3-triazol-1-yl)acetyl)-2-benzyloxycarbonylamino-3-methylbutanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-(6-Amino-9-ethyl-9H-purin-8-yl)-1H-1,2,3-triazol-1-yl)acetamide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
Z-Val-ONp;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 5.25h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water; mineral oil;
Inert atmosphere;
DOI:10.1016/j.tet.2013.08.023
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; bromine / methanol; tetrahydrofuran / 24 h / 20 °C / pH 4.2 / Cooling with ice
2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
3.1: polymer-supported fluoride / tetrahydrofuran / 24 h / 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 0.33 h / 80 °C / Microwave irradiation; Inert atmosphere
4.2: 2 h / 80 °C / Microwave irradiation; Inert atmosphere
5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
5.2: 5.25 h / 0 - 20 °C / Inert atmosphere
5.3: Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; bromine; sodium hydride; acetic acid;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.08.023
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
2.1: polymer-supported fluoride / tetrahydrofuran / 24 h / 20 °C
3.1: sodium azide / N,N-dimethyl-formamide / 0.33 h / 80 °C / Microwave irradiation; Inert atmosphere
3.2: 2 h / 80 °C / Microwave irradiation; Inert atmosphere
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
4.2: 5.25 h / 0 - 20 °C / Inert atmosphere
4.3: Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.08.023
