ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate
• CAS No.: 131448-03-8
• Molecular Formula: C₁₇H₁₅N₃O₄
• Molecular Weight: 325.324

Synonyms:ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

Chemical Property of ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

Chemical Property:

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Technology Process of ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

There total 2 articles about ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl isocyanate (103-71-9) + diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (91558-58-6) → N-carboethoxyaniline (101-99-5) + ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate (131448-03-8)

Guidance literature:

With sodium ethanolate; Yield given. Multistep reaction; 1.) 45 min, 60 deg C 2.) benzene, EtOH, 2 h, reflux;

Reference yield:

phenyl isocyanate (103-71-9) + diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (91558-58-6) → ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate (131448-03-8) + 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylic acid (131448-05-0)

Guidance literature:

Yield given. Multistep reaction;

Reference yield: 88.0%

ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate (131448-03-8) + 2-(diethylamino)ethyl chloride (100-35-6) → ethyl 1(β-diethylaminoethyl)-3-phenyl-7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate (131448-12-9)

Guidance literature:

With sodium ethanolate; for 20h; Heating; 1.) ethanol 2.) benzene;

upstream raw materials:

phenyl isocyanate

diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate

Downstream raw materials:

ethyl 1(β-diethylaminoethyl)-3-phenyl-7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

ethyl 1-(4-bromobutyl)-3-phenyl-7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

1-Ethyl-7-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

1-Allyl-7-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

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