N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide

Base Information

• Chemical Name: N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide
• CAS No.: 1264737-72-5
• Molecular Formula: C₁₄H₉ClF₃NO₂S
• Molecular Weight: 347.745
• Mol file: 1264737-72-5.mol

Synonyms:N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide

Chemical Property of N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide

There total 6 articles about N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzoyl chloride (98-88-4) + S-((p-chloro)phenyl)-S-(trifluoromethyl)-sulfoximine (95414-69-0) → N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide (1264737-72-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1055/s-0033-1338440

Reference yield: 74.0%

N-benzoyl-4-chlorophenyl sulfonimidoyl fluoride (1264737-60-1) + (trifluoromethyl)trimethylsilane (81290-20-2) → N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide (1264737-72-5)

Guidance literature:

N-benzoyl-4-chlorophenyl sulfonimidoyl fluoride; (trifluoromethyl)trimethylsilane; In tetrahydrofuran; at 21 ℃; for 0.166667h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 21 ℃; for 12.5h; Inert atmosphere;

DOI:10.1021/ol103030w

Reference yield:

N-((4-chlorophenyl)sulfinyl)benzamide (342401-19-8) → N-[(4-chlorophenyl)-oxo-(trifluoromethyl)-λ6-sulfanylidene]benzamide (1264737-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert-butylhypochlorite / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 21 °C / Inert atmosphere

3.1: tetrahydrofuran / 0.17 h / 21 °C / Inert atmosphere

3.2: 12.5 h / 21 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; tert-butylhypochlorite; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/ol103030w

upstream raw materials:

N-((4-chlorophenyl)sulfinyl)benzamide

N-benzoyl-4-chlorophenyl sulfonimidoyl fluoride

(trifluoromethyl)trimethylsilane

p-chlorobenzenesulphinamide