methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

Base Information

Chemical Name:methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate
CAS No.:496060-86-7
Molecular Formula:C₃₂H₃₂ClNO₄
Molecular Weight:530.063
Hs Code.:

Synonyms:methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

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Chemical Property of methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

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Technology Process of methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

There total 10 articles about methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496063-04-8
C₂₆H₂₈BrNO₄

: 1679-18-1
4-Chlorophenylboronic acid

: 496060-86-7
methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; for 48h; Reflux;

Reference yield:

: 496060-84-5
2-{6-bromo-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid

: 1679-18-1
4-Chlorophenylboronic acid

: 496060-86-7
methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

Guidance literature:: With sodium hydrogencarbonate; Pd(dppf)Cl₂; In 1,2-dimethoxyethane; hexane; water; ethyl acetate;

Reference yield:

: 98-88-4
benzoyl chloride

: 496060-86-7
methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 0.5 h / 75 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

2.2: 1 h / -78 - -10 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 90 °C

4.1: lithium borohydride / tetrahydrofuran / 20 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

6.2: 3 h / 50 °C

7.1: sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 48 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium borohydride; sodium hydride; sodium hydrogencarbonate; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;