(2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine

Base Information

• Chemical Name: (2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine
• CAS No.: 1042366-93-7
• Molecular Formula: C₁₄H₁₄ClN₅
• Molecular Weight: 287.752
• Mol file: 1042366-93-7.mol

Synonyms:(2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine

Chemical Property of (2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine

There total 1 articles about (2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-(2-chloro-4-pyrimidinyl)-N-(3-methyl-1H-indazol-6-yl)amine (444731-66-2) + methyl iodide (74-88-4) → N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine (444731-75-3) + (2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine (1042366-93-7)

Guidance literature:

N-(2-chloro-4-pyrimidinyl)-N-(3-methyl-1H-indazol-6-yl)amine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/jm800566m

Reference yield: 79.0%

(2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine (1042366-93-7) + 5-amino-2-methylbenzenesulfonamide (6973-09-7) → 5-(4-[(1,3-dimethyl-1H-indazol-6-yl)methylamino]-pyrimidin-2-ylamino)-2-methylbenzenesulfonamide hydrochloride

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; for 18h; Reflux;

DOI:10.1021/acs.oprd.9b00117

Reference yield: 66.0%

(2-chloropyrimidin-4-yl)-(1,3-dimethyl-1H-indazol-6-yl)-methylamine (1042366-93-7) + m-aminobenzenesulfonamide (98-18-0) → 3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)benzenesulfonamide hydrochloride (1042366-82-4)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; for 16h; Reflux;

DOI:10.1021/jm800566m

upstream raw materials:

N-(2-chloro-4-pyrimidinyl)-N-(3-methyl-1H-indazol-6-yl)amine

methyl iodide

Downstream raw materials:

3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)benzenesulfonamide hydrochloride