methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Base Information

Chemical Name:methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride
CAS No.:124082-55-9
Molecular Formula:C₁₉H₂₁Cl₂NO₃*ClH
Molecular Weight:418.748
Hs Code.:

Synonyms:methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Suppliers and Price of methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

There total 10 articles about methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 67-56-1
methanol

: 124082-54-8
3-amino-5-(2-benzyloxy-3,5-dichlorophenyl)pentanoic acid

: 124082-55-9
methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Guidance literature:: With thionyl chloride; for 72h; Ambient temperature;

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 124082-55-9
methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃ / acetone / 4 h / Heating

2: 97 percent / N,N-diethylaniline / 12 h / Heating

3: 79 percent / K₂CO₃ / dimethylformamide / 8 h / Heating

4: 1.) borane-THF complex, 2.) 3M aq. NaOH, 30percent v/v H₂O₂ / 1.) THF, 6 deg C -> room temperature, 2 h, 2.) H₂O, 50 deg C, 1 h

5: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1.) 10 deg C, 1 h, 2.) room temperature, 1 h

6: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

7: 90 percent / KOH / acetone; H₂O / 6 h / Heating

8: 53 percent / liquid NH₃ / 18 h / 120 °C

9: 94 percent / SOCl₂ / 72 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; thionyl chloride; borane-THF; ammonia; dihydrogen peroxide; sodium acetate; sodium hydride; potassium carbonate; pyridinium chlorochromate; N,N-diethylaniline; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 100-39-0
benzyl bromide

: 124082-55-9
methyl 3-amino-5-(2-benzyloxy-4,6-dichlorophenyl)pentanoate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / K₂CO₃ / dimethylformamide / 8 h / Heating

2: 1.) borane-THF complex, 2.) 3M aq. NaOH, 30percent v/v H₂O₂ / 1.) THF, 6 deg C -> room temperature, 2 h, 2.) H₂O, 50 deg C, 1 h

3: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1.) 10 deg C, 1 h, 2.) room temperature, 1 h

4: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

5: 90 percent / KOH / acetone; H₂O / 6 h / Heating

6: 53 percent / liquid NH₃ / 18 h / 120 °C

7: 94 percent / SOCl₂ / 72 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; thionyl chloride; borane-THF; ammonia; dihydrogen peroxide; sodium acetate; sodium hydride; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;