1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Base Information

• Chemical Name: 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole
• CAS No.: 89544-81-0
• Molecular Formula: C₁₁H₁₀Cl₂N₆O
• Molecular Weight: 313.146

Synonyms:1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Chemical Property of 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Chemical Property:

Purity/Quality:

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Technology Process of 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

There total 5 articles about 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane (132507-95-0,81886-66-0) → 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole (89544-81-0)

Guidance literature:

With sodium azide; ammonium chloride; In methanol; for 15h; Heating;

DOI:10.1016/j.bmcl.2008.02.027

Reference yield:

1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (58905-16-1) → 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole (89544-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsulfoxonium iodide; sodium hydroxide / toluene / 4 h / 60 °C

2: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C

With sodium azide; trimethylsulfoxonium iodide; sodium hydroxide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2019.07.003

Reference yield:

2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)oxirane methanesulphonate → 1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole (89544-81-0)

Guidance literature:

In dimethylformamide [DMF]; dichloromethane; water;

upstream raw materials:

1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane

2,2',4'-trichloroacetophenone

1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Downstream raw materials:

5-(2,4-Dichlorophenyl)-5-(1H-1,2,4-triazol-1-yl-methyl)-1,3-oxazolidin-2-on

1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

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