1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Base Information

Chemical Name:1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole
CAS No.:89544-54-7
Molecular Formula:C₁₁H₁₂Cl₂N₄O
Molecular Weight:287.148
Hs Code.:

Synonyms:1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

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Chemical Property of 1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

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Technology Process of 1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

There total 4 articles about 1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 89544-81-0
1-[3-Azido-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

: 89544-54-7
1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 16h; under 3750.38 Torr;
DOI:10.1016/j.bmcl.2008.02.027

Reference yield:

: 58905-16-1
1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

: 89544-54-7
1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsulfoxonium iodide; sodium hydroxide / toluene / 4 h / 60 °C

2: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C

3: hydrogen; palladium 10% on activated carbon / isopropyl alcohol / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; trimethylsulfoxonium iodide; sodium hydroxide; In N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1016/j.ejmech.2019.07.003

Reference yield:

: 132507-95-0,81886-66-0
1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane

: 89544-54-7
1-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NaN₃, NH₄Cl / dimethylformamide / 1.5 h / 90 °C

2: 98 percent / H₂ / 10percent Pd/C / ethanol / 1 h / Ambient temperature

With sodium azide; hydrogen; ammonium chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2476