4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

Base Information

Chemical Name:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile
CAS No.:1436405-38-7
Molecular Formula:C₁₉H₁₄ClIN₄O
Molecular Weight:476.704
Hs Code.:

Synonyms:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

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Chemical Property of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

Chemical Property:

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Technology Process of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

There total 7 articles about 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1160848-89-4
4-chloro-5-iodo-6-methylnicotinonitrile

: 524955-09-7
3-chloro-4-(2-pyridylmethoxy)aniline

: 1436405-38-7
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

Guidance literature:: With methanesulfonic acid; In ethanol; at 70 ℃; for 2h;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1436405-38-7
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 60 °C

2.1: hydrogenchloride; iron / water; ethanol / 1 h / 70 °C

3.1: methanesulfonic acid / ethanol / 2 h / 70 °C

With hydrogenchloride; methanesulfonic acid; iron; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 1160848-88-3,1436405-37-6
4-hydroxy-5-iodo-6-methylnicotinamide

: 1436405-38-7
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / diethylene glycol dimethyl ether / 2 h / 90 °C

2: methanesulfonic acid / ethanol / 2 h / 70 °C

With methanesulfonic acid; trichlorophosphate; In ethanol; diethylene glycol dimethyl ether;
DOI:10.1016/j.bmc.2013.03.053