2,4-difluoro-3-methoxybenzoyl chloride

Base Information

• Chemical Name: 2,4-difluoro-3-methoxybenzoyl chloride
• CAS No.: 221221-11-0
• Molecular Formula: C₈H₅ClF₂O₂
• Molecular Weight: 206.576
• Hs Code.: 2916399090
• Mol file: 221221-11-0.mol

Synonyms:2,4-difluoro-3-methoxybenzoyl chloride

Chemical Property of 2,4-difluoro-3-methoxybenzoyl chloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2,4-Difluoro-3-methoxybenzoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-difluoro-3-methoxybenzoyl chloride

There total 6 articles about 2,4-difluoro-3-methoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-difluoro-3-methoxy-benzoic acid (178974-97-5) → 2,4-difluoro-3-methoxybenzoyl chloride (221221-11-0)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.10.135

Reference yield:

2,4-difluoro-3-methoxy-benzoic acid (178974-97-5) + oxalyl dichloride (79-37-8) → 2,4-difluoro-3-methoxybenzoyl chloride (221221-11-0)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1,3-Difluorobenzene (372-18-9) → 2,4-difluoro-3-methoxybenzoyl chloride (221221-11-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: propyllithium / hexane; toluene / 1 h / -50 °C / Inert atmosphere

1.2: 6 h / -50 - -30 °C

1.3: 30 h / 50 °C

2.1: n-butyllithium / hexane; 2-methyltetrahydrofuran / 2 h / -60 - -50 °C / Inert atmosphere

2.2: 3 h / -40 - -30 °C / Inert atmosphere

3.1: thionyl chloride / 6 h / Reflux

With n-butyllithium; thionyl chloride; propyllithium; In 2-methyltetrahydrofuran; hexane; toluene;

upstream raw materials:

2,4-difluoro-3-methoxy-benzoic acid

oxalyl dichloride

1,3-Difluorobenzene

2,6-difluorophenylboronic acid

Downstream raw materials:

C₂₀H₁₃F₂NO₂S

ethyl 2-(2,4-difluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylate

ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid