2,4-diphenylbenzo[h]quinoline

Base Information

• Chemical Name: 2,4-diphenylbenzo[h]quinoline
• CAS No.: 34987-58-1
• Molecular Formula: C₂₅H₁₇N
• Molecular Weight: 331.417
• Mol file: 34987-58-1.mol

Synonyms:2,4-diphenylbenzo[h]quinoline

Chemical Property of 2,4-diphenylbenzo[h]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-diphenylbenzo[h]quinoline

There total 23 articles about 2,4-diphenylbenzo[h]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-benzylidenenaphthalen-1-amine (890-51-7) + acetophenone (98-86-2) → 2,4-diphenylbenzo[h]quinoline (34987-58-1)

Guidance literature:

With indium(III) triflate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/acs.joc.7b03151

Reference yield: 91.0%

1-amino-naphthalene (134-32-7) + benzaldehyde (100-52-7) + phenylacetylene (536-74-3) → 2,4-diphenylbenzo[h]quinoline (34987-58-1)

Guidance literature:

With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; for 12h; Reagent/catalyst; Catalytic behavior; Reflux;

DOI:10.1039/c7nj00764g

Reference yield: 90.0%

1-amino-naphthalene (134-32-7) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → 2,4-diphenylbenzo[h]quinoline (34987-58-1)

Guidance literature:

With phosphorus pentoxide; silica gel; toluene-4-sulfonic acid; In neat (no solvent); at 155 ℃; for 48h; Inert atmosphere;

DOI:10.1002/cjoc.201700128

upstream raw materials:

1,2,4-Triphenyl-5,6-dihydro-benzo[h]quinolinium; fluoride

2,4-Diphenyl-1-pyrimidin-2-yl-5,6-dihydro-benzo[h]quinolinium; fluoride

1-(4-Bromo-phenyl)-2,4-diphenyl-5,6-dihydro-benzo[h]quinolinium; fluoride

1-(4-Chloro-phenyl)-2,4-diphenyl-5,6-dihydro-benzo[h]quinolinium; fluoride

Refernces

• 1、 Campos, Pedro J.,Anon, Elena,Malo, M. Carmen,Tan, Cheng-Quan,Rodriguez, Miguel A.. "Synthesis of substituted benzoquinolines by the irradiation of 3-amino- 2-alkene imines". . p. 6929 - 6938. Retrieved 1998.
• 2、 Selvi, Thangavel,Velmathi, Sivan. "Indium(III) triflate-catalyzed reactions of AZA-michael adducts of chalcones with aromatic amines: Retro-michael addition versus quinoline formation". . p. 4087 - 4091. Retrieved 2018/04/14.