5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-8-ol

Base Information

• Chemical Name: 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-8-ol
• CAS No.: 156817-68-4
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.169
• European Community (EC) Number: 866-765-5
• Nikkaji Number: J603.916B
• ChEMBL ID: CHEMBL4560719
• Mol file: 156817-68-4.mol

Synonyms:5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-8-ol;156817-68-4;Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI);5H,6H,7H,8H-imidazo[1,2-a]pyridin-8-ol;CHEMBL4560719;SCHEMBL23704527;AKOS027325666;AT24570;CS-0102360;EN300-261176;Z1255451700;Imidazo[1,2-a]pyridin-8-ol,5,6,7,8-tetrahydro-(9ci)

Chemical Property of 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-8-ol

Chemical Property:

• Boiling Point: 365.0±25.0 °C(Predicted)
• PKA: 13.48±0.20(Predicted)
• PSA: 38.05000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 0.71030
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

5H,6H,7H,8H-imidazo[1,2-a]pyridin-8-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(C2=NC=CN2C1)O

Technology Process of 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-8-ol

There total 5 articles about 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

8-(phenylmethoxy)imidazo[1,2-a]pyridine (96428-16-9) → hydroxy-8 tetrahydro-5,6,7,8 imidazo<1,2-a>pyridine (156817-68-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 48h;

Reference yield: 61.0%

2,2-diethoxy-ethanamine (645-36-3) + 3-hydroxypiperidin-2-one (19365-08-3,220928-01-8) → hydroxy-8 tetrahydro-5,6,7,8 imidazo<1,2-a>pyridine (156817-68-4)

Guidance literature:

titanium tetrachloride; In 1,3,5-trimethyl-benzene; for 72h; Heating;

DOI:10.1021/jo00096a066

Reference yield:

2-amino-3-benzyloxypyridine (24016-03-3) → hydroxy-8 tetrahydro-5,6,7,8 imidazo<1,2-a>pyridine (156817-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaHCO₃ / ethanol; H₂O / 8 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 22 h / 2250.2 Torr / Ambient temperature

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; water;

upstream raw materials:

2,2-diethoxy-ethanamine

3-hydroxypiperidin-2-one

8-(phenylmethoxy)imidazo[1,2-a]pyridine

2-amino-3-hydroxypyridine

Downstream raw materials:

6,7-dihydroimidazo[1,2-a]pyridine-8(5H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 156817-68-4 Imidazo[1,2-a]pyridin-8-ol, 5,6,7,8-tetrahydro- (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send