(4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone

Base Information

• Chemical Name: (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone
• CAS No.: 1343404-04-5
• Molecular Formula: C₁₆H₁₅FN₄O₃
• Molecular Weight: 330.319
• Mol file: 1343404-04-5.mol

Synonyms:(4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone

Chemical Property of (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone

There total 3 articles about (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-fluorobenzoyl chloride (403-43-0) + 1-(5-nitro-2-pyridinyl)piperazine (82205-58-1) → (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone (1343404-04-5)

Guidance literature:

With polymer-supported N-methylmorpholine; In dichloromethane; for 16h;

DOI:10.1016/j.tetlet.2011.07.147

Reference yield:

2-bromo-5-nitropyridine (4487-59-6) → (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone (1343404-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / water / 0.25 h / 150 °C / Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 20 °C

3.1: polymer-supported N-methylmorpholine / dichloromethane / 16 h

With potassium carbonate; trifluoroacetic acid; In dichloromethane; water;

DOI:10.1016/j.tetlet.2011.07.147

Reference yield:

tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate (193902-78-2) → (4-fluorophenyl)(4-(5-nitropyridin-2-yl)piperazin-1-yl)methanone (1343404-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: polymer-supported N-methylmorpholine / dichloromethane / 16 h

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2011.07.147

upstream raw materials:

2-bromo-5-nitropyridine

tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

4-fluorobenzoyl chloride

1-(5-nitro-2-pyridinyl)piperazine

Downstream raw materials:

(4-(5-aminopyridin-2-yl)piperazin-1-yl)(4-fluorophenyl)methanone