(3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

Base Information

Chemical Name:(3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone
CAS No.:1446517-26-5
Molecular Formula:C₁₉H₁₁F₄NO₂
Molecular Weight:361.295
Hs Code.:

Synonyms:(3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

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Chemical Property of (3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

Chemical Property:

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Technology Process of (3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

There total 3 articles about (3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 349-95-1
4-(trifluoromethyl)benzylic alcohol

: 1357293-53-8
2-(2-fluorophenoxy)pyridine

: 1446517-26-5
(3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

Guidance literature:: With tert.-butylhydroperoxide; palladium diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 20h; regioselective reaction; Sealed tube;
DOI:10.1016/j.tet.2013.06.008

Reference yield:

: 367-12-4
2-fluorophenol

: 1446517-26-5
(3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 120 °C / Inert atmosphere

2: palladium diacetate; tert.-butylhydroperoxide / 1,2-dichloro-ethane / 20 h / 80 °C / Sealed tube

With tert.-butylhydroperoxide; 2,2,6,6-tetramethylheptane-3,5-dione; palladium diacetate; caesium carbonate; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2013.06.008

Reference yield:

: 109-09-1
2-chloropyridine

: 1446517-26-5
(3-fluoro-2-(pyridin-2-yloxy)phenyl)(4-(trifluoromethyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 120 °C / Inert atmosphere

2: palladium diacetate; tert.-butylhydroperoxide / 1,2-dichloro-ethane / 20 h / 80 °C / Sealed tube

With tert.-butylhydroperoxide; 2,2,6,6-tetramethylheptane-3,5-dione; palladium diacetate; caesium carbonate; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2013.06.008