1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil

Base Information

• Chemical Name: 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil
• CAS No.: 1187742-94-4
• Molecular Formula: C₂₅H₂₇N₃O₃
• Molecular Weight: 417.508

Synonyms:1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil

Chemical Property of 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil

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Technology Process of 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil

There total 2 articles about 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide (1187743-04-9) → 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil (1187742-94-4)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; at 90 ℃; Inert atmosphere;

DOI:10.1002/hlca.200900039

Reference yield: 13.0%

p-aminoiodobenzene (540-37-4) + 6-(3,5-dimethyl-benzyl)-5-ethyl-1-prop-2-ynyloxymethyl-1H-pyrimidine-2,4-dione (488702-38-1) → 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil (1187742-94-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; Inert atmosphere;

DOI:10.1002/hlca.200900039

Reference yield: 90.0%

bromoacetic anhydride (13094-51-4) + 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil (1187742-94-4) → 2-bromo-N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]acetamide (1187743-05-0)

Guidance literature:

at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/hlca.200900039

upstream raw materials:

N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide

p-aminoiodobenzene

6-(3,5-dimethyl-benzyl)-5-ethyl-1-prop-2-ynyloxymethyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

2-bromo-N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]acetamide

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