(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Chemical Name:(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
CAS No.:1358778-54-7
Molecular Formula:C₂₁H₂₇N₃O₆S
Molecular Weight:449.528
Hs Code.:

Synonyms:(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Chemical Property of (2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Technology Process of (2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

There total 4 articles about (2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1358778-53-6
(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)butanoic acid

: 1358778-54-7
(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 2-methyltetrahydrofuran; at 20 ℃;
DOI:10.1021/jm2014875

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1358778-54-7
(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 0.02 h / Resolution of racemate

2: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 2 h / Reflux

3: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; tetrabutylammomium bromide; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.1021/jm2014875

Reference yield:

: 1312478-48-0
(2R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1358778-54-7
(2R)-2-methyl-2-(methylsulfonyl)-4-(6-oxo-4-phenylpyridazin-1(6H)-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 2 h / Reflux

2: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

3: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; tetrabutylammomium bromide; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jm2014875