7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

Base Information

Chemical Name:7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline
CAS No.:1428796-74-0
Molecular Formula:C₁₁H₁₂BrNO
Molecular Weight:254.126
Hs Code.:

Synonyms:7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

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Chemical Property of 7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of 7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

There total 1 articles about 7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90151-40-9
4-amino-3-methoxybenzaldehyde

: 1428796-74-0
7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: n-Butyl nitrite; copper(I) bromide / acetonitrile / 18 h / 20 °C

2: ammonium acetate; acetic acid / 18 h / 80 °C

3: sodium tetrahydroborate; borane-THF / tetrahydrofuran / 18 h / 0 - 65 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5: trichlorophosphate / toluene / 2 h / 110 °C

With sodium tetrahydroborate; borane-THF; n-Butyl nitrite; ammonium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; copper(I) bromide; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1428796-74-0
7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

: 1428796-07-9
(R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; triethylamine / acetonitrile / 2 h / 100 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1.75 h / 85 °C / Inert atmosphere; Sealed tube

3.1: water; sodium hydroxide / ethanol / 3 h / 75 °C

3.2: pH 1

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h

5.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 22.5 h / Inert atmosphere; Sealed tube

5.2: 2 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; palladium diacetate; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1428796-74-0
7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline

: 1428796-81-9
ethyl 9-ethyl-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; triethylamine / acetonitrile / 2 h / 100 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 18.5 h / 90 °C / Inert atmosphere; Sealed tube

3: palladium 10% on activated carbon; hydrogen / ethanol / 72 h / Inert atmosphere

4: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 41.25 h / 90 - 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; acetonitrile;