methyl 5-amino-1-benzyl-1H-1,2,3-triazole-4-carboxylate

Base Information

• Chemical Name: methyl 5-amino-1-benzyl-1H-1,2,3-triazole-4-carboxylate
• CAS No.: 103742-39-8
• Molecular Formula: C₁₁H₁₂N₄O₂
• Molecular Weight: 232.242
• Mol file: 103742-39-8.mol

Synonyms:methyl 5-amino-1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxylate

Chemical Property of methyl 5-amino-1-benzyl-1H-1,2,3-triazole-4-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl5-Amino-1-benzyl-1H-1,2,3-triazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of methyl 5-amino-1-benzyl-1H-1,2,3-triazole-4-carboxylate

There total 3 articles about methyl 5-amino-1-benzyl-1H-1,2,3-triazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

cyanoacetic acid (372-09-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + benzyl azide (622-79-7) → methyl 5-amino-1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxylate (103742-39-8)

Guidance literature:

at 120 ℃; for 48h;

DOI:10.3390/molecules24101996

Reference yield:

benzyl bromide (100-39-0) → methyl 5-amino-1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxylate (103742-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; sodium hydroxide / water; acetone / 24 h / 20 °C

2: 48 h / 120 °C

With sodium azide; sodium hydroxide; In water; acetone;

DOI:10.3390/molecules24101996

Reference yield:

benzyl azide (622-79-7) + methyl 2-cyanoacetate (105-34-0) → methyl 5-amino-1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxylate (103742-39-8)

Guidance literature:

With sodium methylate;

upstream raw materials:

benzyl azide

methyl 2-cyanoacetate

benzyl bromide

cyanoacetic acid

Downstream raw materials:

1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

(Z)-3-(5-Amino-1-benzyl-1H-[1,2,3]triazol-4-yl)-2-phenyl-acrylonitrile

5-Amino-3-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-carbonitrile

3-Benzyl-5-oxo-4,5-dihydro-3H-[1,2,3]triazolo[4,5-b]pyridine-6-carbonitrile

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