N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester
CAS No.:116565-03-8
Molecular Formula:C₁₆H₂₃NO₅
Molecular Weight:309.362
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

There total 12 articles about N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: (3S)-3-[(t-butoxycarbonyl)amino]-1-(diphenylphosphinoyl)-1,1-dimethoxy-4-phenyl-2-butanol

: 116565-03-8
N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: (3S)-3-[(t-butoxycarbonyl)amino]-1-(diphenylphosphinoyl)-1,1-dimethoxy-4-phenyl-2-butanol; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With AD-mix-α; methanesulfonamide; In water; tert-butyl alcohol; at 0 ℃; for 4h; Further stages.;
DOI:10.1002/ejoc.200300631

Reference yield: 66.3%

: 116565-03-8
N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:

Reference yield: 25.0%

: 67-56-1
methanol

: tert-butyl (S)-(4-cyano-3-oxo-1-phenyl-4-(triphenyl-λ⁵-phosphanylidene)butan-2-yl)carbamate

: 116565-03-8
N-(tert-butyloxycarbonyl)-(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

: 116565-10-7
(2R,3S)-N-(tert-butoxycarbonyl)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: tert-butyl (S)-(4-cyano-3-oxo-1-phenyl-4-(triphenyl-λ⁵-phosphanylidene)butan-2-yl)carbamate; With ozone; In dichloromethane; at -78 ℃; Inert atmosphere;

methanol; With sodium tetrahydroborate; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1007/s00044-020-02678-2