3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid

Base Information

• Chemical Name: 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid
• CAS No.: 1612842-40-6
• Molecular Formula: C₁₂H₁₁BrFNO₃
• Molecular Weight: 316.127
• Mol file: 1612842-40-6.mol

Synonyms:3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid

Chemical Property of 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid

There total 4 articles about 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-1-iodobenzene (352-34-1) → 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid (1612842-40-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 5 h / 0 - 20 °C / Inert atmosphere

4.1: bromine / diethyl ether / 2 h / 0 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; lithium hydroxide monohydrate; bromine; tert.-butyl lithium; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.3390/molecules19022655

Reference yield:

piperidin-2-one (675-20-7) → 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid (1612842-40-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 5 h / 0 - 20 °C / Inert atmosphere

4.1: bromine / diethyl ether / 2 h / 0 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; lithium hydroxide monohydrate; bromine; tert.-butyl lithium; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.3390/molecules19022655

Reference yield:

1-(4-fluorophenyl)piperidin-2-one (27471-40-5) → 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid (1612842-40-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

1.2: 0.17 h / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 5 h / 0 - 20 °C / Inert atmosphere

3.1: bromine / diethyl ether / 2 h / 0 °C / Inert atmosphere

With lithium hydroxide monohydrate; bromine; tert.-butyl lithium; In tetrahydrofuran; methanol; diethyl ether; water;

DOI:10.3390/molecules19022655

upstream raw materials:

4-fluoro-1-iodobenzene

piperidin-2-one

1-(4-fluorophenyl)piperidin-2-one

isobutyl 1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate

Downstream raw materials:

3-chloro-4-(4-(3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)-2-fluorophenoxy)-picolinamide

N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide