Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

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Chemical Name:Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester
CAS No.:179676-60-9
Molecular Formula:C₃₂H₃₁N₇O₁₄
Molecular Weight:737.637
Hs Code.:

Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

Synonyms:Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

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Chemical Property of Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

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Technology Process of Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

There total 3 articles about Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108-30-5
succinic acid anhydride

: 177084-28-5
Carbonic acid (2S,4R,5R)-4-hydroxy-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester 2-(4-nitro-phenyl)-ethyl ester

: 179676-60-9
Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

Guidance literature:: With dmap; In dichloromethane; N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1002/hlca.19960790304

Reference yield:

: 88091-68-3
2-(4-nitrophenyl)ethoxycarbonyl chloride

: 179676-60-9
Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / pyridine; CH₂Cl₂ / 1.67 h / -10 °C

2: 90 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 48 h / Ambient temperature

With dmap; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790304

Reference yield:

: 112237-60-2
3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

: 179676-60-9
Succinic acid mono-{(2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / pyridine; CH₂Cl₂ / 1.67 h / -10 °C

2: 90 percent / 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 48 h / Ambient temperature

With dmap; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790304