5-cyano-2,4-dimethyl-N-phenyl-6-thioxo-1,6-dihydro-3-pyridinecarboxamide

Base Information

• Chemical Name: 5-cyano-2,4-dimethyl-N-phenyl-6-thioxo-1,6-dihydro-3-pyridinecarboxamide
• CAS No.: 303190-15-0
• Molecular Formula: C₁₅H₁₃N₃OS
• Molecular Weight: 283.354
• Mol file: 303190-15-0.mol

Synonyms:3-cyano-4,6-dimethyl-5-phenylcarbamoylpyridin-2(1H)-thione

Chemical Property of 5-cyano-2,4-dimethyl-N-phenyl-6-thioxo-1,6-dihydro-3-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyano-2,4-dimethyl-N-phenyl-6-thioxo-1,6-dihydro-3-pyridinecarboxamide

There total 1 articles about 5-cyano-2,4-dimethyl-N-phenyl-6-thioxo-1,6-dihydro-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Cyanothioacetamide (7357-70-2) + N-phenylacetoacetamide (102-01-2,98624-45-4) + acetaldehyde (75-07-0,9002-91-9) → 3-cyano-4,6-dimethyl-5-phenylcarbamoylpyridin-2(1H)-thione (303190-15-0)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 20 ℃; for 16h;

DOI:10.1007/BF02256865

Reference yield: 91.0%

3-cyano-4,6-dimethyl-5-phenylcarbamoylpyridin-2(1H)-thione (303190-15-0) + methyl iodide (74-88-4) → 3-cyano-4,6-dimethyl-2-methylthio-5-phenylcarbamoylpyridine (303190-17-2)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 1h;

DOI:10.1007/BF02256865

Reference yield: 72.0%

3-cyano-4,6-dimethyl-5-phenylcarbamoylpyridin-2(1H)-thione (303190-15-0) + Chloroacetamide (79-07-2) → 3-amino-2-carbamoyl-4,6-dimethyl-5-phenylcarbamoylthieno[2,3-b]pyridine

Guidance literature:

3-cyano-4,6-dimethyl-5-phenylcarbamoylpyridin-2(1H)-thione; Chloroacetamide; In N,N-dimethyl-formamide; for 3h;

With potassium hydroxide; In water; N,N-dimethyl-formamide; for 1h;

DOI:10.1007/BF02256865

upstream raw materials:

Cyanothioacetamide

N-phenylacetoacetamide

acetaldehyde

Downstream raw materials:

3-cyano-4,6-dimethyl-2-methylthio-5-phenylcarbamoylpyridine