[3-¹⁴C]1-triphenylsilyl-3-phenylpropyne

Base Information

• Chemical Name: [3-¹⁴C]1-triphenylsilyl-3-phenylpropyne
• CAS No.: 1420878-92-7
• Molecular Formula: C₂₇H₂₂Si
• Molecular Weight: 376.546
• Mol file: 1420878-92-7.mol

Synonyms:[3-¹⁴C]1-triphenylsilyl-3-phenylpropyne

Chemical Property of [3-¹⁴C]1-triphenylsilyl-3-phenylpropyne

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [3-¹⁴C]1-triphenylsilyl-3-phenylpropyne

There total 3 articles about [3-¹⁴C]1-triphenylsilyl-3-phenylpropyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

[1-14C]benzylbromide (15314-26-8) + triphenylsilylacetylene (6229-00-1) → [3-14C]1-triphenylsilyl-3-phenylpropyne (1420878-92-7)

Guidance literature:

triphenylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.5h; Inert atmosphere;

[1-¹⁴C]benzylbromide; With copper(l) iodide; In tetrahydrofuran; hexane; at -78 - 60 ℃; for 20h; Inert atmosphere;

DOI:10.1002/jlcr.2963

Reference yield:

[carbonyl-(14)C]benzoic acid (1589-66-8) → [3-14C]1-triphenylsilyl-3-phenylpropyne (1420878-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 20 °C / Inert atmosphere

3.2: 20 h / -78 - 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1002/jlcr.2963

Reference yield:

[1-14C]benzyl alcohol (13057-53-9) → [3-14C]1-triphenylsilyl-3-phenylpropyne (1420878-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - 20 °C / Inert atmosphere

2.2: 20 h / -78 - 60 °C / Inert atmosphere

With n-butyllithium; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1002/jlcr.2963

upstream raw materials:

[carbonyl-(14)C]benzoic acid

[1-¹⁴C]benzyl alcohol

[1-¹⁴C]benzylbromide

triphenylsilylacetylene

Downstream raw materials:

4-[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydro-2H-quinazolin-3-ylmethyl]benzoic acid

4-[1-methyl-2,4-dioxo-6-(3-phenyl-[3-¹⁴C]prop-1-ynyl)-1,4-dihydro-2Hquinazolin-3-ylmethyl]benzoic acid