ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Base Information

Chemical Name:ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate
CAS No.:1076220-89-7
Molecular Formula:C₂₁H₁₉BrF₃NO₃
Molecular Weight:470.286
Hs Code.:

Synonyms:ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Suppliers and Price of ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

There total 4 articles about ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076220-88-6
ethyl 2-(4-amino-3-bromo-5-iodophenyl)-2-methylpropanoate

: 160542-02-9
1-ethynyl-4-(trifluoromethoxy)benzene

: 1076220-89-7
ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Guidance literature:: With copper(l) iodide; triethylamine; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 103962-05-6
1-iodo-4-(trifluoromethoxy)benzene

: 1076220-89-7
ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran;

Reference yield:

: 357193-01-2
ethyl 2-(4-amino-3-iodophenyl)-2-methylpropanoate

: 1076220-89-7
ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium tribromide / tetrahydrofuran / 0.75 h / 20 °C

2: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

With copper(l) iodide; pyridinium tribromide; triethylamine; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran;