8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Base Information

Chemical Name:8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide
CAS No.:1240017-56-4
Molecular Formula:C₂₉H₃₆N₂O₆
Molecular Weight:508.615
Hs Code.:

Synonyms:8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

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Chemical Property of 8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

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Technology Process of 8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

There total 7 articles about 8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1163716-52-6
(2S)-1-(4-methoxyphenyl)but-3-en-2-amine

: 10349-38-9
p-methoxyphenylisonitrile

: 64-19-7,77671-22-8
acetic acid

: 1240017-56-4
8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Guidance literature:: In methanol; at 20 ℃; for 72h;
DOI:10.1016/j.tetlet.2010.05.089

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1240017-56-4
8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine; tert-butylmagnesium chloride / tetrahydrofuran / 0 - 20 °C

3.1: sodium tetrahydroborate / methanol / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

5.1: potassium thioacyanate / water; ethanol / 24 h / 20 - 60 °C

5.2: 12 h / 80 °C

6.1: hydrogenchloride / methanol; water / 24 h / 20 °C

7.1: methanol / 84 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; tert-butylmagnesium chloride; potassium thioacyanate; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 7.1: |Ugi Condensation;
DOI:10.3987/COM-12-S(N)38

Reference yield:

: 1240017-62-2
C₁₆H₂₃NO₄

: 1240017-56-4
8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium thioacyanate / water; ethanol / 24 h / 20 - 60 °C

1.2: 12 h / 80 °C

2.1: hydrogenchloride / methanol; water / 24 h / 20 °C

3.1: methanol / 84 h / 20 °C

With hydrogenchloride; potassium thioacyanate; In methanol; ethanol; water; 3.1: |Ugi Condensation;
DOI:10.3987/COM-12-S(N)38