methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate

Base Information

• Chemical Name: methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate
• CAS No.: 1240017-55-3
• Molecular Formula: C₂₃H₃₃NO₆
• Molecular Weight: 419.518

Synonyms:methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate

Chemical Property of methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate

Chemical Property:

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Technology Process of methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate

There total 9 articles about methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide (1240017-56-4) + trimethyl orthoformate (149-73-5) → methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate (1240017-55-3)

Guidance literature:

With 10-camphorsufonic acid; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2010.05.089

Reference yield: 93.0%

methanol (67-56-1) + C33H42N2O8 → methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate (1240017-55-3)

Guidance literature:

With camphor-10-sulfonic acid; trimethyl orthoformate; at 20 ℃;

DOI:10.3987/COM-12-S(N)38

Reference yield: 85.0%

methanol (67-56-1) + 8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide (1240017-56-4) → methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate (1240017-55-3)

Guidance literature:

With camphor-10-sulfonic acid; trimethyl orthoformate; at 20 ℃; for 16h;

DOI:10.3987/COM-12-S(N)38

upstream raw materials:

8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide

trimethyl orthoformate

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate

Downstream raw materials:

8,8-dimethoxy-1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,4-dione

1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

(2S)-2-(2,8-dioxo-1-azaspiro[4.5]dec-1-yl)-3-(4-methoxyphenyl)propanal

(5S,6R,7R,10aR)-6-hydroxy-5-(4-methoxybenzyl)tetrahydro-1H-7,10a-methanopyrrolo[1,2-a]azocine-3,8(2H,5H)-dione

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