(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

Base Information

Chemical Name:(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide
CAS No.:1246766-12-0
Molecular Formula:C₂₄H₂₇N₅O₂
Molecular Weight:417.511
Hs Code.:

Synonyms:(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

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Chemical Property of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

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Technology Process of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

There total 9 articles about (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1246765-54-7
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid

: 74-89-5
methylamine

: 1246766-12-0
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

Guidance literature:: (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 0.333333h;

methylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm500206r

Reference yield: 92.0%

: 1246766-12-0
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

Guidance literature:

Reference yield:

: 1246765-25-2
methyl 6-(3-cyclopentylacryloyl)-2-methoxynicotinate

: 1246766-12-0
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 3 h / 80 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: chiralpak AD-H / methanol / Resolution of racemate; Supercritical conditions

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.33 h

3.2: 12 h / 20 °C

With sodium ethanolate; 1,1'-carbonyldiimidazole; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm500206r