(-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

Base Information

Chemical Name:(-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole
CAS No.:224571-77-1
Molecular Formula:C₁₈H₂₈N₂O₃Si
Molecular Weight:348.517
Hs Code.:

Synonyms:(-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

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Chemical Property of (-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

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Technology Process of (-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

There total 4 articles about (-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 196314-29-1
(-)-(1R,2S,5R)-8-phenylmenthyl 3-((4R,5S)-1-tert-butoxycarbonyl-4,5-dihydro-4-phenyl-5-trimethylsilyl-1H-pyrazole)carboxylate

: 224571-77-1
(-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 16h; Ambient temperature;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 224571-77-1
(-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

2: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / Ambient temperature

With sodium tetrahydroborate; In tetrahydrofuran; methanol;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0

Reference yield:

: 119240-64-1
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (E)-3-phenylpropenoate

: 224571-77-1
(-)-(4S,5S)-1-tert-butoxycarbonyl-4,5-dihydro-3-hydroxymethyl-4-phenyl-5-trimethylsilyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: hexane; tetrahydrofuran / 192 h / 67 °C

2: NEt₃, DMAP / hexane; tetrahydrofuran / 2 h / Ambient temperature

3: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / Ambient temperature

With dmap; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; hexane;
DOI:10.1002/(SICI)1521-3765(19990301)5:3<883::AID-CHEM883>3.0.CO;2-0