methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

Base Information

Chemical Name:methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate
CAS No.:1363553-50-7
Molecular Formula:C₁₉H₂₃Cl₄NO₆
Molecular Weight:503.207
Hs Code.:

Synonyms:methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

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Chemical Property of methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

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Technology Process of methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

There total 5 articles about methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1363553-48-3
methyl 2-(5,6-dimethoxyisoindolin-2-yl)pent-4-enoate

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1363553-50-7
methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

Guidance literature:: In 1,2-dichloro-ethane; Reflux; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1363553-50-7
methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen bromide; acetic acid / 12 h / 20 °C / Inert atmosphere

2: lithium chloride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 72 h / 20 °C / Inert atmosphere

4: acetonitrile / 45 h / 20 °C / Inert atmosphere

5: potassium tert-butylate / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere

6: 1,2-dichloro-ethane / Reflux; Inert atmosphere

With potassium tert-butylate; tetrabutyl-ammonium chloride; hydrogen bromide; acetic acid; lithium chloride; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; 5: Stevens rearrangement;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 1363553-46-1
Br^(1-)*C₁₆H₂₂NO₄⁽¹⁺⁾

: 1363553-50-7
methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere

2: 1,2-dichloro-ethane / Reflux; Inert atmosphere

With potassium tert-butylate; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Stevens rearrangement;
DOI:10.1016/j.tetlet.2012.01.013