N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

Base Information

Chemical Name:N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide
CAS No.:226992-16-1
Molecular Formula:C₂₅H₃₁N₃O₅S₂
Molecular Weight:517.67
Hs Code.:

<i>N</i>-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

Synonyms:N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

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Chemical Property of N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

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Technology Process of N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

There total 12 articles about N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 124-63-0
methanesulfonyl chloride

: 312315-39-2
N-[4-(2-{[2-(4-amino-phenyl)-ethyl]-benzyl-amino}-ethoxy)-phenyl]-methanesulfonamide

: 226992-16-1
N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0960-894X(00)00412-1

Reference yield: 78.4%

: 124-63-0
methanesulfonyl chloride

: 226992-15-0
N-benzyl-N-[2-(p-aminophenoxy)ethyl]-p-(amino)phenethylamine

: 226992-16-1
N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm010574u

Reference yield:

: 6270-07-1
N-<2-(4-nitrophenyl)ethyl>acetamide

: 226992-16-1
N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / 47percent HBr / 6 h / Heating

2: 81.5 percent / K₂CO₃ / acetonitrile / 20 °C

3: 61 percent / K₂CO₃ / acetonitrile / 3.5 h / Heating

4: 87 percent / aq. HCl; iron; ammonium chloride / acetone / 45 °C

5: 78.4 percent / Et₃N / CH₂Cl₂

With hydrogenchloride; ammonium chloride; iron; potassium carbonate; triethylamine; In dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm010574u