Acetamide, N-(2-methyl-1H-indol-3-yl)-

Base Information

• Chemical Name: Acetamide, N-(2-methyl-1H-indol-3-yl)-
• CAS No.: 154876-18-3
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.229
• Mol file: 154876-18-3.mol

Synonyms:Acetamide, N-(2-methyl-1H-indol-3-yl)-

Chemical Property of Acetamide, N-(2-methyl-1H-indol-3-yl)-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

N-(2-methyl-1H-indol-3-yl)-Acetamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N-(2-methyl-1H-indol-3-yl)-

There total 3 articles about Acetamide, N-(2-methyl-1H-indol-3-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phenylhydrazine (100-63-0) + N-Acetylpropargylamine (65881-41-6) → 3-acetamido-2-methylindole (154876-18-3)

Guidance literature:

With zinc dibromide; In 1,2-dimethoxyethane; at 110 ℃; for 20h; regioselective reaction; Inert atmosphere;

DOI:10.1039/b920861e

Reference yield: 75.0%

acetic acid (64-19-7,77671-22-8) + 1-(2-methyl-3-indolyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester → 3-acetamido-2-methylindole (154876-18-3)

Guidance literature:

With zinc; for 0.75h; Ambient temperature;

DOI:10.1021/jo00082a035

Reference yield:

2-methyl-1H-indole (95-20-5) → 3-acetamido-2-methylindole (154876-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether / 1.5 h / 8 °C

2: 75 percent / Zn / 0.75 h / Ambient temperature

With zinc; In diethyl ether;

DOI:10.1021/jo00082a035

upstream raw materials:

acetic acid

2-methyl-1H-indole

phenylhydrazine

N-Acetylpropargylamine

Refernces

• 1、 Mitchell, Helen,Leblanc, Yves. "Amination of Arenes with Electron-Deficient Azodicarboxylates". . p. 682 - 687. Retrieved 2007/10/02.