[(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester

Base Information

• Chemical Name: [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester
• CAS No.: 916885-76-2
• Molecular Formula: C₂₀H₂₄N₂O₄
• Molecular Weight: 356.422
• Mol file: 916885-76-2.mol

Synonyms:[(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester

Chemical Property of [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester

There total 4 articles about [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-pyridinecarbonyl chloride (10400-19-8) + [(4-Methoxy-benzyl)-amino]-acetic Acid Tert-butyl Ester (98076-56-3) → [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester (916885-76-2)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/ol062126s

Reference yield:

nicotinic acid (59-67-6) → [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester (916885-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / 40 - 50 °C

2: 99 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With pyridine; dmap; thionyl chloride; In dichloromethane;

DOI:10.1021/ol062126s

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester (916885-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / triethylamine / tetrahydrofuran / 0 - 20 °C

2: 99 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With pyridine; dmap; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol062126s

upstream raw materials:

3-pyridinecarbonyl chloride

[(4-Methoxy-benzyl)-amino]-acetic Acid Tert-butyl Ester

nicotinic acid

bromoacetic acid tert-butyl ester