N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide

Base Information

• Chemical Name: N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide
• CAS No.: 144369-40-4
• Molecular Formula: C₁₂H₁₆INO₄
• Molecular Weight: 365.168
• Mol file: 144369-40-4.mol

Synonyms:N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide

Chemical Property of N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide

There total 4 articles about N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide (155955-78-5) → N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide (144369-40-4)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1039/c9cc01679a

Reference yield:

(2-iodo-4,5-dimethoxyphenyl)acetic acid (35323-09-2) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide (144369-40-4)

Guidance literature:

With triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02665

Reference yield:

(2-iodo-4,5-dimethoxyphenyl)acetic acid (35323-09-2) → N,O-dimethyl-4,5-dimethoxy-2-iodobenzylamide (144369-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / Heating

2: HCl, pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; thionyl chloride; In dichloromethane; benzene;

DOI:10.1016/S0040-4039(00)79113-1

upstream raw materials:

(2-iodo-4,5-dimethoxyphenyl)acetyl chloride

N,0-dimethylhydroxylamine

(2-iodo-4,5-dimethoxyphenyl)acetic acid

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

4,5-dimethoxy-2-methylbenzaldehyde