(1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

Base Information

Chemical Name:(1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate
CAS No.:371162-59-3
Molecular Formula:C₃₄H₃₈O₄Si
Molecular Weight:538.759
Hs Code.:

Synonyms:(1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

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Technology Process of (1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

There total 3 articles about (1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 135822-23-0
(R)-1-(trimethylsilyloxy)-1-<1,2,2-triphenyl-2-(trimethylsilyloxy)ethoxy>-1-propene

: 98-86-2
acetophenone

: 371162-59-3
(1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1002/1099-0690(200108)2001:16<3155::AID-EJOC3155>3.0.CO;2-8

Reference yield:

: 135789-37-6
(R)-2-hydroxy-1,2,2-triphenylethyl propionate

: 371162-59-3
(1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Li(iPr)2

2: 78 percent / titanium tetrachloride / CH₂Cl₂ / 3 h / -78 °C

With titanium tetrachloride; lithium diisopropyl amide; In dichloromethane;
DOI:10.1002/1099-0690(200108)2001:16<3155::AID-EJOC3155>3.0.CO;2-8

Reference yield:

: 135822-23-0
(R)-1-(trimethylsilyloxy)-1-<1,2,2-triphenyl-2-(trimethylsilyloxy)ethoxy>-1-propene

: 98-86-2
acetophenone

: 3-Hydroxy-2-methyl-3-phenyl-butyric acid (R)-1,2,2-triphenyl-2-trimethylsilanyloxy-ethyl ester

: 371162-59-3
(1R)-1,2,2-triphenyl-2-(trimethylsilyloxy)ethyl (2S,3R)-3-hydroxy-2,3-dimethyl-3-phenylpropanoate

Guidance literature:: (R)-1-(trimethylsilyloxy)-1-<1,2,2-triphenyl-2-(trimethylsilyloxy)ethoxy>-1-propene; acetophenone; With titanium tetrachloride; In dichloromethane;

With water; In dichloromethane;
DOI:10.1055/s-1999-2885