Docetaxel Hydroxy-tert-butyl-carbamate

Base Information

Chemical Name:Docetaxel Hydroxy-tert-butyl-carbamate
CAS No.:154044-57-2
Molecular Formula:C₄₃H₅₃NO₁₅
Molecular Weight:823.892
Hs Code.:
Mol file:154044-57-2.mol

Synonyms:Benzenepropanoicacid, a-hydroxy-b-[[(2-hydroxy-1,1-dimethylethoxy)carbonyl]amino]-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-;7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.;RPR 104952

Suppliers and Price of Docetaxel Hydroxy-tert-butyl-carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DocetaxelHydroxytert-Butylcarbamate
1mg
$ 215.00

Medical Isotopes, Inc.
DocetaxelHydroxy-tert-butyl-carbamate
5 mg
$ 9800.00

Biosynth Carbosynth
Docetaxel hydroxy tert-butylcarbamate
1 mg
$ 955.50

American Custom Chemicals Corporation
DOCETAXEL HYDROXY-TERT-BUTYL-CARBAMATE 95.00%
1MG
$ 1386.00

American Custom Chemicals Corporation
DOCETAXEL HYDROXY-TERT-BUTYL-CARBAMATE 95.00%
0.5MG
$ 1045.00

Total 3 raw suppliers

Chemical Property of Docetaxel Hydroxy-tert-butyl-carbamate

Chemical Property:

Melting Point:165-168°C
Refractive Index:1.628
Boiling Point:932.9±65.0 °C(Predicted)
PKA:10.86±0.46(Predicted)
PSA：244.68000
Density:1.41±0.1 g/cm3(Predicted)
LogP:2.62290
Storage Temp.:-20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

DocetaxelHydroxytert-Butylcarbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Docetaxel, an antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin The main metabolite of Docetaxel (D494420), an antineoplastic.

Technology Process of Docetaxel Hydroxy-tert-butyl-carbamate

There total 3 articles about Docetaxel Hydroxy-tert-butyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 160651-89-8
N-de-t-butoxycarbonyl-N-2-(1-hydroxy-2-methyl)propyloxycarbonyl-7,10-O-diTroc-docetaxel

: 154044-57-2
RPR 104952

Guidance literature:: With zinc; In methanol; acetic acid; at 60 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)81761-0

Reference yield:

: 154044-76-5
2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate

: 154044-57-2
RPR 104952

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / pyridine / 7 h / Ambient temperature

2: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / CH₂Cl₂; H₂O / 1 h / Ambient temperature

3: 60 percent / Zn / methanol; acetic acid / 0.25 h / 60 °C

With pyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In methanol; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(01)81761-0

Reference yield:

: 154044-74-3
N-de-t-butoxycarbonyl-N-2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyloxycarbonyl-7,10-O-diTroc-docetaxel

: 154044-57-2
RPR 104952

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / CH₂Cl₂; H₂O / 1 h / Ambient temperature

2: 60 percent / Zn / methanol; acetic acid / 0.25 h / 60 °C

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In methanol; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(01)81761-0