N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

Base Information

• Chemical Name: N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel
• CAS No.: 160651-89-8
• Molecular Formula: C49H55Cl6NO19
• Molecular Weight: 1174.6743
• Mol file: 160651-89-8.mol

Synonyms:N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel;[2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-α-Hydroxy-β-[[(2-hydroxy-1,1-diMethylethoxy)carbonyl]aMino]benzenepropanoic Acid 12b-(Acet

Chemical Property of N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

Chemical Property:

• PSA: 275.28000
• LogP: 7.68510

Purity/Quality:

97% ^*data from raw suppliers

N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl}Docetaxel ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

There total 2 articles about N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-de-t-butoxycarbonyl-N-2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyloxycarbonyl-7,10-O-diTroc-docetaxel (154044-74-3) → N-de-t-butoxycarbonyl-N-2-(1-hydroxy-2-methyl)propyloxycarbonyl-7,10-O-diTroc-docetaxel (160651-89-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81761-0

Reference yield:

2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate (154044-76-5) → N-de-t-butoxycarbonyl-N-2-(1-hydroxy-2-methyl)propyloxycarbonyl-7,10-O-diTroc-docetaxel (160651-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / pyridine / 7 h / Ambient temperature

2: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With pyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;

DOI:10.1016/S0040-4020(01)81761-0

Reference yield: 60.0%

N-de-t-butoxycarbonyl-N-2-(1-hydroxy-2-methyl)propyloxycarbonyl-7,10-O-diTroc-docetaxel (160651-89-8) → RPR 104952 (154044-57-2)

Guidance literature:

With zinc; In methanol; acetic acid; at 60 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)81761-0

upstream raw materials:

N-de-t-butoxycarbonyl-N-2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyloxycarbonyl-7,10-O-diTroc-docetaxel

2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate

Downstream raw materials:

RPR 104952

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