(4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

Base Information

Chemical Name:(4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]
CAS No.:868658-72-4
Molecular Formula:C₂₇H₃₀N₂O₄
Molecular Weight:446.546
Hs Code.:

Synonyms:(4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

Suppliers and Price of (4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

Chemical Property:

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Technology Process of (4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

There total 4 articles about (4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 135112-68-4
(S)-3-[4-allyloxyphenyl]-2-aminopropanol

: 10344-69-1
diethyl malonoimidate dihydrochloride

: 868658-72-4
(4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

Guidance literature:: In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.tetasy.2005.08.013

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 868658-72-4
(4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Bu₄NI; K₂CO₃ / dimethylformamide / 18 h / 20 °C

2: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

3: 88 percent / sodium borohydride / methanol / 2 h / 35 °C

4: 55 percent / CH₂Cl₂ / 48 h / 20 °C

With sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.08.013

Reference yield:

: 127802-97-5
(S)-O-allyl-tyrosine methyl ester

: 868658-72-4
(4S,4'S)-2,2'-methylenebis[4-(4-allyloxybenzyl)-4,5-dihydro-1,3-oxazole]

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / sodium borohydride / methanol / 2 h / 35 °C

2: 55 percent / CH₂Cl₂ / 48 h / 20 °C

With sodium tetrahydroborate; In methanol; dichloromethane;
DOI:10.1016/j.tetasy.2005.08.013