127802-97-5

Upstream product

• 147363-14-2 C₃₇H₄₉BrN₂O₁₀ 
• 147363-13-1 N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide 
• 147363-12-0 tert-butyl (S)-(3-(4-(allyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 147363-23-3 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate 

Downstream Products

• 135112-68-4 (S)-3-[4-allyloxyphenyl]-2-aminopropanol 
• 1228019-32-6 C₂₂H₂₇NO₅ 
• 1610043-28-1 methyl (2S)-3-(4-allyloxyphenyl)-2-[[5-[3-(4-allyloxyphenyl)propanoyl]-1H-pyrrole-2-carbonyl]amino]propanoate 
• 55288-06-7 H-Phe-Tyr-OMe 

Relevant academic research and scientific papers

A mild copper catalyzed method for the selective deprotection of aryl allyl ethers

Copper boryl reagents enable the selective cleavage of aryl allyl ethers to the corresponding phenols in good to moderate yields.

Design and synthesis of β-strand-fixed peptides inhibiting aggregation of amyloid β-protein

Aggregation of 42-residue amyloid β-protein (Aβ42) can be prevented by β-sheet breaker peptides (BSBps) homologous to LVFFA residues, which are included in a β-sheet region of Aβ42 aggregates. To enhance the affinity of BSBps to the Aβ42 aggregates, we de

Construction of the cyclophane core of the hirsutellones via a RCM strategy

Construction of the highly strained [10]-paracyclophane core of the hirsutellones has been completed via an effective RCM strategy.

Synthesis of two new chiral fluorous bis(oxazolines) and their applications as ligands in catalytic asymmetric reactions

Two new chiral fluorous bis(oxazolines) with a fluorous content of 56.9% and 59.3%, respectively, have been prepared starting from (S)-serine and (S)-tyrosine. Applications of these compounds as fluorous box ligands in asymmetric alkylations gave ees up to 92%, and in allylic oxidations ees up to 50%. Recycling and reuse of the ligands in asymmetric alkylation and of the catalytic system in allylic oxidation gave the same enantioselectivities.

Practical Synthesis of a Highly Enantioselective Receptor for Peptides

A practical synthesis of a highly enantioselective, C3-symmetric host molecule (2) has been developed.The basic strategy is a significant improvement over the relatively lenghty previous synthesis and involves direct addition of a Boc-tyrosine amide anion derivative 4 to methyl 3,5-bis(bromomethyl)benzoate to give an advanced intermediate (5).The final step, a triple macrolactamization, closes three 19-membered rings simultaneously to produce the bridged macrotricyclic receptor in 70-80percent yield.