<4S<4α(R),5β,6α(1R,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

Base Information

Chemical Name:<4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde
CAS No.:106734-82-1
Molecular Formula:C₂₆H₄₀O₇
Molecular Weight:464.599
Hs Code.:

Synonyms:<4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

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Chemical Property of <4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

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Technology Process of <4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

There total 20 articles about <4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 114597-35-2
(R)-2-[(4R,5R,6S)-6-((1S,2R)-2-Benzyloxymethoxy-4-[1,3]dioxolan-2-yl-1-methyl-butyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propan-1-ol

: 106734-82-1
<4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/ja00221a043

Reference yield:

: 106734-76-3
(2R,3R,4R)-2-((1S,2R)-2-Benzyloxymethoxy-4-[1,3]dioxolan-2-yl-1-methyl-butyl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol

: 106734-82-1
<4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: p-TsOH / benzene

2: 1.) BH₃, 2.) H₂O₂, NaOH / 1.) THF

3: 1.) (COCl)2, DMSO, 2.) Et₃N

4: L-Selectride

5: DDQ

6: LiBH₄

8: 1.) PPTS, 2.) Bu₄NF, 3.) (COCl)2, DMSO, 4.) Et₃N

With sodium hydroxide; lithium borohydride; oxalyl dichloride; borane; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridinium p-toluenesulfonate; L-Selectride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene;
DOI:10.1021/ja00239a049

Reference yield:

: 114597-32-9
(2R,3R,4R,5R,6R,7R)-7-Benzyloxymethoxy-9-[1,3]dioxolan-2-yl-2,4,6-trimethyl-nonane-1,3,5-triol

: 106734-82-1
<4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) PPTS, 2.) Bu₄NF, 3.) (COCl)2, DMSO, 4.) Et₃N

With oxalyl dichloride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine;
DOI:10.1021/ja00239a049