2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

Base Information

Chemical Name:2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine
CAS No.:1350352-72-5
Molecular Formula:C₄H₁₁N*C₁₆H₁₆N₂O₃S
Molecular Weight:389.519
Hs Code.:

Synonyms:2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

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Chemical Property of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

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Technology Process of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

There total 13 articles about 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 75-64-9
tert-butylamine

: 144060-53-7
febuxostat

: 1350352-72-5
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 34133-58-9
4-hydroxy-isophthalonitrile

: 1350352-72-5
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / dimethyl sulfoxide / 16 h / 70 - 75 °C

2: hydrogenchloride; thioacetamide / isopropyl alcohol / 14 h / 40 - 45 °C

3: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C

4: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C

5: toluene / 10 h

With hydrogenchloride; ethanol; potassium carbonate; thioacetamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 615-58-7
2,4-dibromophenol

: 1350352-72-5
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

Guidance literature:: Multi-step reaction with 6 steps

1: palladium diacetate / dimethyl sulfoxide / 4 h / 40 - 45 °C

2: potassium carbonate; potassium iodide / dimethyl sulfoxide / 16 h / 70 - 75 °C

3: hydrogenchloride; thioacetamide / isopropyl alcohol / 14 h / 40 - 45 °C

4: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C

5: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C

6: toluene / 10 h

With hydrogenchloride; ethanol; potassium carbonate; thioacetamide; potassium iodide; sodium hydroxide; palladium diacetate; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;