methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

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Chemical Name:methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate
CAS No.:1616372-04-3
Molecular Formula:C₂₁H₂₃ClN₄O₂
Molecular Weight:398.892
Hs Code.:

Synonyms:methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

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Chemical Property of methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

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Technology Process of methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

There total 6 articles about methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1616372-02-1
4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616372-04-3
methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

Guidance literature:: With hydrogenchloride; at 85 ℃; for 5h; Sealed tube;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616372-04-3
methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 9 h / 0 - 25 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 h / 100 °C

4.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: sulfuric acid; 1,1'-bis-(diphenylphosphino)ferrocene; zinc; palladium diacetate / N,N-dimethyl acetamide / 14.5 h / 80 - 95 °C / Inert atmosphere; Sealed tube

6.1: hydrogenchloride / 5 h / 85 °C / Sealed tube

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; borane-THF; carbon tetrabromide; sulfuric acid; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 3937-49-3
(trans-4-methylcyclohexyl)methanol

: 1616372-04-3
methyl 4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 h / 100 °C

3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: sulfuric acid; 1,1'-bis-(diphenylphosphino)ferrocene; zinc; palladium diacetate / N,N-dimethyl acetamide / 14.5 h / 80 - 95 °C / Inert atmosphere; Sealed tube

5.1: hydrogenchloride / 5 h / 85 °C / Sealed tube

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; carbon tetrabromide; sulfuric acid; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; zinc; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;