3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

Base Information

Chemical Name:3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester
CAS No.:1260620-82-3
Molecular Formula:C₃₆H₄₈FN₃O₅Si
Molecular Weight:649.878
Hs Code.:

3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

Synonyms:3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

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Chemical Property of 3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

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Technology Process of 3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

There total 5 articles about 3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1260620-74-3
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

: 917752-46-6
ethyl (3R)-(tert-butyldimethylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)-hexanoate

: 1260620-82-3
3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

Guidance literature:: In toluene; at 90 ℃; for 36h; optical yield given as %ee; Reflux;
DOI:10.1021/op100268e

Reference yield:

: C₁₈H₂₃FN₂O₄

: 1260620-82-3
3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water

2.2: 16 h / 20 °C

3.1: toluene / 36 h / 90 °C / Reflux

With sodium hydroxide; In methanol; water; toluene; 3.1: Wittig reaction;
DOI:10.1021/op100268e

Reference yield:

: 1260620-81-2
1-(4-fluorophenyl)-4-isopropyl-5-styryl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1260620-82-3
3-(tert-butyl-dimethyl-silanyloxy)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-5-oxo-hept-6-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: ozone / methanol; dichloromethane / 1.5 h / -60 °C / Large scale reaction

1.2: 1 h / 0 °C / Inert atmosphere; Large scale reaction

2.1: 4 h

3.2: 16 h / 20 °C

4.1: toluene / 36 h / 90 °C / Reflux

With ozone; In methanol; dichloromethane; toluene; 4.1: Wittig reaction;
DOI:10.1021/op100268e