1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

Base Information

Chemical Name:1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide
CAS No.:1260620-74-3
Molecular Formula:C₂₂H₂₂FN₃O₂
Molecular Weight:379.434
Hs Code.:

Synonyms:1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

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Chemical Property of 1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

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Technology Process of 1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

There total 4 articles about 1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887703-77-7
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid

: 104-84-7
para-methylbenzylamine

: 1260620-74-3
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

Guidance literature:: 1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid; With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃;

para-methylbenzylamine; In dichloromethane; at 25 ℃; Further stages.;
DOI:10.1021/jm070849r

Reference yield:

: C₁₈H₂₃FN₂O₄

: 1260620-74-3
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; water

2.2: 16 h / 20 °C

With sodium hydroxide; In methanol; water;
DOI:10.1021/op100268e

Reference yield:

: 1260620-81-2
1-(4-fluorophenyl)-4-isopropyl-5-styryl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1260620-74-3
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone / methanol; dichloromethane / 1.5 h / -60 °C / Large scale reaction

1.2: 1 h / 0 °C / Inert atmosphere; Large scale reaction

2.1: 4 h

3.2: 16 h / 20 °C

With ozone; In methanol; dichloromethane;
DOI:10.1021/op100268e