1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Base Information

Chemical Name:1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide
CAS No.:887703-70-0
Molecular Formula:C₂₈H₃₂FN₃O₄
Molecular Weight:493.578
Hs Code.:

1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Synonyms:

Suppliers and Price of 1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

There total 10 articles about 1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260620-85-6
7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

: 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid

: 887703-70-0
1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Guidance literature:: 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester; With sodium hydroxide; In ethanol; water; at 15 - 25 ℃; for 2h;

With acetic acid; In water; at 65 ℃;
DOI:10.1021/op100268e

Reference yield:

: 887703-77-7
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid

: 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid

: 887703-70-0
1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.2: 16 h / 20 °C

2.1: toluene / 36 h / 90 °C / Reflux

3.1: hydrogen fluoride / water; acetonitrile / 19.5 h / 0 - 20 °C

4.1: diethylmethoxyborane / tetrahydrofuran; methanol / 1 h / -78 - -72 °C

4.2: -72 - -30 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol; water / 4 h / 20 - 25 °C / 2585.81 Torr / Inert atmosphere

6.1: sodium hydroxide / ethanol; water / 2 h / 15 - 25 °C

6.2: 65 °C

With diethylmethoxyborane; palladium 10% on activated carbon; hydrogen fluoride; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene; acetonitrile; 2.1: Wittig reaction;
DOI:10.1021/op100268e

Reference yield:

: 1260620-74-3
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methylbenzylamide

: 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid

: 887703-70-0
1-(4-fluoro-phenyl)-5-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-4-isopropyl-1H-pyrazole-3-carboxylic acid 4-methyl-benzylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 36 h / 90 °C / Reflux

2.1: hydrogen fluoride / water; acetonitrile / 19.5 h / 0 - 20 °C

3.1: diethylmethoxyborane / tetrahydrofuran; methanol / 1 h / -78 - -72 °C

3.2: -72 - -30 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol; water / 4 h / 20 - 25 °C / 2585.81 Torr / Inert atmosphere

5.1: sodium hydroxide / ethanol; water / 2 h / 15 - 25 °C

5.2: 65 °C

With diethylmethoxyborane; palladium 10% on activated carbon; hydrogen fluoride; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene; acetonitrile; 1.1: Wittig reaction;
DOI:10.1021/op100268e