7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

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Chemical Name:7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester
CAS No.:1260620-85-6
Molecular Formula:C₃₀H₃₈FN₃O₅
Molecular Weight:539.647
Hs Code.:

Synonyms:7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

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Chemical Property of 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

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Technology Process of 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

There total 8 articles about 7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1260620-84-5
7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester

: 1260620-85-6
7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 - 25 ℃; for 4h; under 2585.81 Torr; Inert atmosphere;
DOI:10.1021/op100268e

Reference yield:

: 887703-77-7
1-(4-fluorophenyl)-5-formyl-4-isopropyl-1H-pyrazole-3-carboxylic acid

: 1260620-85-6
7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.2: 16 h / 20 °C

2.1: toluene / 36 h / 90 °C / Reflux

3.1: hydrogen fluoride / water; acetonitrile / 19.5 h / 0 - 20 °C

4.1: diethylmethoxyborane / tetrahydrofuran; methanol / 1 h / -78 - -72 °C

4.2: -72 - -30 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol; water / 4 h / 20 - 25 °C / 2585.81 Torr / Inert atmosphere

With diethylmethoxyborane; palladium 10% on activated carbon; hydrogen fluoride; hydrogen; In tetrahydrofuran; methanol; ethanol; water; toluene; acetonitrile; 2.1: Wittig reaction;
DOI:10.1021/op100268e

Reference yield:

: 1260620-83-4
7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3-hydroxy-5-oxo-hept-6-enoic acid ethyl ester

: 1260620-85-6
7-[2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylmethoxyborane / tetrahydrofuran; methanol / 1 h / -78 - -72 °C

1.2: -72 - -30 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol; water / 4 h / 20 - 25 °C / 2585.81 Torr / Inert atmosphere

With diethylmethoxyborane; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/op100268e