6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

Base Information

Chemical Name:6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine
CAS No.:135345-87-8
Molecular Formula:C₂₄H₂₅ClN₄O₃
Molecular Weight:452.941
Hs Code.:

Synonyms:6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

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Chemical Property of 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

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Technology Process of 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

There total 8 articles about 6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

: 123240-66-4
4,6-dichloro-5-formamidopyrimidine

: 135345-86-7
2,2-bis(benzyloxymethyl)cyclopropylamine

: 135345-87-8
6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

Guidance literature:: With triethylamine; In 1,4-dioxane; for 16h; Heating;
DOI:10.1039/P19920002519

Reference yield:

: 27441-79-8
2-methylenepropane-1,3-bisbenzyl ether

: 135345-87-8
6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: 56.2 percent / cupric sulfate / 0.5 h / 90 °C

2: 84.7 percent / KOH / methanol / Ambient temperature

3: 1.) ClCO₂Et, Et₃N, 2.) NaN₃ / 1.) acetone, 0 deg C, 1 h, 2.) H₂O, room temperature, 1 h

4: 12.8 g / toluene / 1 h / 90 - 100 °C

5: 84.8 percent / 48 h / 90 - 100 °C

6: 100 percent / CF₃CO₂H / 0.33 h / Ambient temperature

7: 90.2 percent / Et₃N / dioxane / 16 h / Heating

With potassium hydroxide; sodium azide; chloroformic acid ethyl ester; copper(II) sulfate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; toluene;
DOI:10.1039/P19920002519

Reference yield:

: 145215-01-6
2,2-Bis-benzyloxymethyl-cyclopropanecarbonyl azide

: 135345-87-8
6-<<2,2-bis(benzyloxymethyl)cyclopropyl>amino>-4-chloro-5-formamidopyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 12.8 g / toluene / 1 h / 90 - 100 °C

2: 84.8 percent / 48 h / 90 - 100 °C

3: 100 percent / CF₃CO₂H / 0.33 h / Ambient temperature

4: 90.2 percent / Et₃N / dioxane / 16 h / Heating

With triethylamine; trifluoroacetic acid; In 1,4-dioxane; toluene;
DOI:10.1039/P19920002519