(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

Base Information

Chemical Name:(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide
CAS No.:1309930-54-8
Molecular Formula:C₃₆H₆₁NO₅Si
Molecular Weight:615.97
Hs Code.:

Synonyms:(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

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Technology Process of (4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

There total 13 articles about (4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1309930-51-5
(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methylcyclohex-1-enyl]-2-hydroxyethyl}-7-methoxydodec-4-enamide

: 74-88-4
methyl iodide

: 1309930-54-8
(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

Guidance literature:: With calcium sulfate; silver(l) oxide; at 40 ℃; for 24h;
DOI:10.1039/c0ob01118e

Reference yield:

: C₂₃H₃₉NO₃Si

: 290354-60-8
(4E,7S)-(-)-7-methoxydodec-4-enoic acid

: 1309930-54-8
(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 8.5h;
DOI:10.1039/c0ob01118e

Reference yield:

: 1309930-46-8
[(1R,5R,6S)-5-benzyloxy-4-iodo-6-methylcyclohex-3-enyloxy]-tert-butyldimethylsilane

: 1309930-54-8
(4E,7S)-N-{(2S)-2-[(4R,5S,6R)-6-benzyloxy-4-(tert-butyldimethylsilyloxy)-5-methyl-cyclohex-1-enyl]-2-methoxyethyl}-7-methoxydodec-4-enamide

Guidance literature:: Multi-step reaction with 4 steps

1: chromium dichloride; nickel dichloride / N,N-dimethyl-formamide / 36 h / 28 °C

2: hydrazine hydrate / ethanol / 2 h / 60 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 8.5 h / 0 - 20 °C

4: calcium sulfate; silver(l) oxide / 24 h / 40 °C

With 4-methyl-morpholine; chromium dichloride; calcium sulfate; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; nickel dichloride; silver(l) oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Nozaki-Hiyama-Kishi reaction;
DOI:10.1039/c0ob01118e