Fmoc-Phe-Lys(Mtt)-PABC-pNP

Base Information

• Chemical Name: Fmoc-Phe-Lys(Mtt)-PABC-pNP
• CAS No.: 1136860-41-7
• Molecular Formula: C₆₄H₅₉N₅O₉
• Molecular Weight: 1042.2
• Mol file: 1136860-41-7.mol

Synonyms:Fmoc-Phe-Lys(Mtt)-PABC-pNP

Chemical Property of Fmoc-Phe-Lys(Mtt)-PABC-pNP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-Phe-Lys(Mtt)-PABC-pNP

There total 5 articles about Fmoc-Phe-Lys(Mtt)-PABC-pNP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Fmoc-Phe-Lys(Mtt)-PABOH (1313201-95-4) + 4-Nitrophenyl chloroformate (7693-46-1) → Fmoc-Phe-Lys(Mtt)-PABC-pNP (1136860-41-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2015.09.050

Reference yield:

4-aminobenzenemethanol (623-04-1) → Fmoc-Phe-Lys(Mtt)-PABC-pNP (1136860-41-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

2: piperidine / N,N-dimethyl-formamide / 0.17 h

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

4: pyridine / dichloromethane / 2 h / 20 °C

With piperidine; pyridine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.09.050

Reference yield:

Fmoc-Lys(Mtt)-PABOH → Fmoc-Phe-Lys(Mtt)-PABC-pNP (1136860-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / N,N-dimethyl-formamide / 0.17 h

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

3: pyridine / dichloromethane / 2 h / 20 °C

With piperidine; pyridine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.09.050

upstream raw materials:

Fmoc-Phe-Lys(Mtt)-PABOH

4-Nitrophenyl chloroformate

4-aminobenzenemethanol