(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

Base Information

Chemical Name:(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide
CAS No.:1353547-75-7
Molecular Formula:C₁₉H₂₄N₂O₈S₂
Molecular Weight:472.54
Hs Code.:

Synonyms:(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

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Chemical Property of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

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Technology Process of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

There total 9 articles about (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1353547-73-5
(E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-amine

: 124-63-0
methanesulfonyl chloride

: 1353547-75-7
(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 13h;
DOI:10.1021/jm4019614

Reference yield:

: 23056-40-8
2-chloro-5-methyl-3-nitro-pyridine

: 1353547-75-7
(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium / 4 h / Reflux; Inert atmosphere

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 48 h / Inert atmosphere; Reflux

3.1: sodium carbonate / methanol / 1 h / 20 °C

4.1: dihydrogen peroxide; acetic acid / 6 h / 60 °C

5.1: water; sodium carbonate / methanol / 4 h / 20 °C

5.2: pH 2

6.1: piperidine; pyridine / 3 h / Inert atmosphere; Reflux

7.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

8.1: pyridine / 20 °C / Cooling with ice

With piperidine; pyridine; N-Bromosuccinimide; water; dihydrogen peroxide; sodium; iron; sodium carbonate; acetic acid; dibenzoyl peroxide; In methanol; tetrachloromethane;

Reference yield:

: 1353547-90-6
5-(bromomethyl)-2-methoxy-3-nitropyridine

: 1353547-75-7
(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / methanol / 1 h / 20 °C

2.1: dihydrogen peroxide; acetic acid / 6 h / 60 °C

3.1: water; sodium carbonate / methanol / 4 h / 20 °C

3.2: pH 2

4.1: piperidine; pyridine / 3 h / Inert atmosphere; Reflux

5.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

6.1: pyridine / 20 °C / Cooling with ice

With piperidine; pyridine; water; dihydrogen peroxide; iron; sodium carbonate; acetic acid; In methanol;