methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

Base Information

Chemical Name:methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate
CAS No.:1309935-53-2
Molecular Formula:C₁₈H₃₀FNO₂Si
Molecular Weight:339.526
Hs Code.:

Synonyms:methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

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Chemical Property of methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

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Technology Process of methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

There total 6 articles about methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 67-56-1
methanol

: 773837-37-9
sodium cyanide

: 1309935-52-1
[4-(di-tert-butylfluorosilanyl)phenyl]acetaldehyde

: 1309935-53-2
methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

Guidance literature:: sodium cyanide; With ammonia; ammonium chloride; In water; at 0 ℃;

methanol; [4-(di-tert-butylfluorosilanyl)phenyl]acetaldehyde; In water; at 0 - 20 ℃;

With hydrogenchloride; In water; for 12h; Reflux;
DOI:10.1002/ejic.201100142

Reference yield:

: 1309935-51-0
2-[4-(di-tert-butylfluorosilanyl)phenyl]ethanol

: 1309935-53-2
methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium chlorochromate / dichloromethane / 0 - 20 °C

2.1: ammonia; ammonium chloride / water / 0 °C

2.2: 0 - 20 °C

2.3: 12 h / Reflux

With ammonia; ammonium chloride; pyridinium chlorochromate; In dichloromethane; water;
DOI:10.1002/ejic.201100142

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1309935-53-2
methyl rac-2-amino-3-[4-(di-tert-butyl-fluoro-silanyl)-phenyl]-propionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 0.25 h / 20 °C

1.2: 22 h / 20 °C

2.1: tert.-butyl lithium / diethyl ether; pentane / 0.25 h / -78 °C

2.2: -78 - 20 °C

3.1: N-iodo-succinimide / methanol / 24 h / 20 °C

4.1: pyridinium chlorochromate / dichloromethane / 0 - 20 °C

5.1: ammonia; ammonium chloride / water / 0 °C

5.2: 0 - 20 °C

5.3: 12 h / Reflux

With 1H-imidazole; N-iodo-succinimide; ammonia; tert.-butyl lithium; ammonium chloride; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; water; pentane;
DOI:10.1002/ejic.201100142